You're describing a compound with a rather complex chemical name. Let's break it down and understand its potential importance:
**1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indolone**
* **1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]**: This part tells us the molecule has a piperazine ring attached to a methyl group, which is further attached to the indole ring. The 2-pyridinyl group attached to the piperazine ring suggests the presence of a pyridine ring.
* **2-benzo[cd]indolone**: This is the core structure of the molecule. It refers to an indole ring fused to a benzene ring. The 2- indicates the position of a carbonyl group (C=O) on the indole ring.
**Why is this compound important for research?**
This specific compound is not commonly known or researched. However, its structure suggests several potential reasons for its importance:
* **Indole Derivatives:** Indole derivatives are known to exhibit diverse biological activities, including anti-inflammatory, antimicrobial, and anticancer properties.
* **Piperazine Ring:** Piperazine rings are commonly found in pharmaceutical compounds, often acting as building blocks for various drug targets.
* **Pyridine Ring:** Pyridine rings are also present in numerous drugs and are known for their ability to interact with biological systems.
**Possible Research Applications:**
* **Drug Discovery:** The compound could potentially be investigated for its pharmacological activity against various diseases.
* **Chemical Biology:** This compound could be used as a probe to study the interactions between indole derivatives, piperazine rings, and pyridine rings with biological targets.
* **Material Science:** Indole derivatives can have interesting optical and electronic properties, potentially leading to applications in material science.
**Important Note:**
Without specific research findings or context, it's impossible to say definitively why this compound is important.
**To learn more about this compound's significance, you would need to:**
* **Search for scientific publications:** Look for articles that mention the compound's name or chemical structure.
* **Contact researchers:** Reach out to researchers working in the areas of medicinal chemistry, drug discovery, or chemical biology.
Let me know if you have any other questions!
ID Source | ID |
---|---|
PubMed CID | 829587 |
CHEMBL ID | 1611337 |
CHEBI ID | 131248 |
Synonym |
---|
OPREA1_785213 |
MLS000098782 , |
smr000061177 |
OPREA1_327935 |
AKOS000808677 |
MLS002633102 |
CHEBI:131248 |
HMS2173L12 |
1-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzo[cd]indol-2(1h)-one |
F1061-0228 |
380458-28-6 |
CHEMBL1611337 |
STL487112 |
1-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}benzo[cd]indol-2(1h)-one |
Z52533131 |
SR-01000010134-1 |
sr-01000010134 |
1-[(4-pyridin-2-ylpiperazin-1-yl)methyl]benzo[cd]indol-2-one |
1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indolone |
Q27225012 |
Class | Description |
---|---|
piperazines | |
pyridines | Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 15.8489 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 5.6234 | 17.2929 | 31.6228 | AID485281 |
Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 0.0020 | 14.6779 | 39.8107 | AID1476; AID1478 |
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 23.9341 | 0.0072 | 15.7588 | 89.3584 | AID588342 |
acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 14.1254 | 24.0613 | 39.8107 | AID504937 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
TDP1 protein | Homo sapiens (human) | Potency | 18.3564 | 0.0008 | 11.3822 | 44.6684 | AID686979 |
importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
snurportin-1 | Homo sapiens (human) | Potency | 44.6684 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 31.6228 | 0.0003 | 11.4484 | 31.6228 | AID900 |
Caspase-7 | Homo sapiens (human) | Potency | 25.1189 | 3.9811 | 18.5856 | 31.6228 | AID889 |
Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 2.2387 | 1.9953 | 25.5327 | 50.1187 | AID624287 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
RNA binding | Caspase-7 | Homo sapiens (human) |
aspartic-type endopeptidase activity | Caspase-7 | Homo sapiens (human) |
cysteine-type endopeptidase activity | Caspase-7 | Homo sapiens (human) |
protein binding | Caspase-7 | Homo sapiens (human) |
peptidase activity | Caspase-7 | Homo sapiens (human) |
cysteine-type peptidase activity | Caspase-7 | Homo sapiens (human) |
cysteine-type endopeptidase activity involved in apoptotic process | Caspase-7 | Homo sapiens (human) |
cysteine-type endopeptidase activity involved in execution phase of apoptosis | Caspase-7 | Homo sapiens (human) |
G protein activity | Guanine nucleotide-binding protein G | Homo sapiens (human) |
adenylate cyclase activator activity | Guanine nucleotide-binding protein G | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular space | Caspase-7 | Homo sapiens (human) |
nucleus | Caspase-7 | Homo sapiens (human) |
cytoplasm | Caspase-7 | Homo sapiens (human) |
cytosol | Caspase-7 | Homo sapiens (human) |
nucleus | Caspase-7 | Homo sapiens (human) |
nucleoplasm | Caspase-7 | Homo sapiens (human) |
cytosol | Caspase-7 | Homo sapiens (human) |
plasma membrane | Guanine nucleotide-binding protein G | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |